This study assessed the awareness on the implementation of International Organization Standardization (ISO) 9001: 2015 in a university and the challenges encountered by the key stakeholders. It also tested the correlation of respondents’ demographic profile to the level of awareness and challenges. The study used a descriptive research design and convenience sampling technique with a total of 100 survey participants from senior officials, professors, faculty, and non-faculty personnel. To collect responses, the study used structured survey questionnaire distributed through Google Forms. Descriptive statistics such as frequency count, percentage, and weighted mean as well as Spearman were used for data analysis. The results of the study showed that employees are ‘Fully Aware’ and ‘Aware’ on the implementation of ISO 9001:2015, particularly in terms of the quality mission, vision, and objectives. However, employees “Disagree” with the various challenges in the implementation of ISO 9001: 2015. In addition, there was no significant relationship among the respondents' profile, awareness and challenges in the implementation of ISO 9001: 2015 at the university. The study found that while university employees are usually aware of the quality management system's fundamental objectives, they normally disagree on the challenges of putting it into practice. For this, information dissemination should be done on a regular basis while the employees are obliged to also internalize the university's quality management system's vision, mission, and objectives.